(2R,3S)-6-Oxo-2,3-diphenyl-morpholine-4-carboxylic acid tert-butyl ester - Names and Identifiers
Name | tert-butyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morph
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Synonyms | CIVENTICHEM CV-2654 CIVENTICHEM CV-2653 (5S,6R)-N-Boc-5,6-diphenyl-2-morpholinone tert-butyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morph N-BOC(2R, 3S)-(-)-6-OXO-2,3-DIPHENYL-4-MORPHOLINE CARBOXYLATE tert-butyl (2S,3S)-6-oxo-2,3-diphenylmorpholine-4-carboxylate tert-butyl (2R,3S)-6-oxo-2,3-diphenylmorpholine-4-carboxylate (2R,3S)-tert-Butyl 6-oxo-2,3- diphenylmorpholine-4-carboxylate tert-Butyl (2R,3S)-()-6-oxo-2,3-diphenyl-4-morpholinecarboxylate N-TERT-BUTOXYCARBONYL-(2R,3S)-(-)-6-OXO-2,3-DIPHENYL-4-MORPHOLINE TERT-BUTYL (2R,3S)-(-)-6-OXO-2,3-DIPHENYL-4-MORPHOLINECARBOXYLATE tert-Butyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate (2R,3S)-6-Oxo-2,3-diphenyl-morpholine-4-carboxylic acid tert-butyl ester
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CAS | 112741-49-8
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InChI | InChI=1/C21H23NO4/c1-21(2,3)26-20(24)22-14-17(23)25-19(16-12-8-5-9-13-16)18(22)15-10-6-4-7-11-15/h4-13,18-19H,14H2,1-3H3/t18-,19+/m0/s1 |
InChIKey | MRUKRSQUUNYOFK-RBUKOAKNSA-N |
(2R,3S)-6-Oxo-2,3-diphenyl-morpholine-4-carboxylic acid tert-butyl ester - Physico-chemical Properties
Molecular Formula | C21H23NO4
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Molar Mass | 353.41 |
Density | 1.175±0.06 g/cm3(Predicted) |
Melting Point | 206°C (dec.)(lit.) |
Boling Point | 509.6±50.0 °C(Predicted) |
Specific Rotation(α) | -87 º (c=5.5 in methylene chloride) |
Flash Point | 262°C |
Solubility | Acetone (Slightly, Heated, Sonicated), Chloroform (Slightly), DMSO (Slightly, So |
Vapor Presure | 1.67E-10mmHg at 25°C |
Appearance | White powder |
Color | White to Off-White |
pKa | -3.28±0.60(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.561 |
MDL | MFCD00074955 |
(2R,3S)-6-Oxo-2,3-diphenyl-morpholine-4-carboxylic acid tert-butyl ester - Risk and Safety
Hazard Symbols | Xi - Irritant
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Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection
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WGK Germany | 3 |
(2R,3S)-6-Oxo-2,3-diphenyl-morpholine-4-carboxylic acid tert-butyl ester - Introduction
(2R,3S)-N-tert-butoxycarbonyl-2, 3-diphenylmorpholin-6-one, also known as (2R,3S)-N-tert-butoxycarbonyl-2,3-diphenyl-6-piperidinone, is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: White crystalline solid;
-melting point: about 112-115 ℃;
-Molecular formula: C25H27NO3;
-Molecular weight: 389.48g/mol;
-Stability: Stable at room temperature.
Use:
(2R,3S)-N-tert-butoxycarbonyl-2, 3-diphenylmorpholin-6-one is an important organic synthesis intermediate, commonly used in the synthesis of drugs and other organic compounds.
Preparation Method:
The preparation of (2R,3S)-N-tert-butoxycarbonyl-2, 3-diphenylmorpholin-6-one can be carried out by the following steps:
1. reacting ethyl benzoate with excess hydrocyanic acid to obtain benzyl benzoate;
2. The nucleophilic addition reaction of benzyl benzoate and diphenylacetonitrile under the catalysis of a base to obtain (2R,3S)-N-tert-butoxycarbonyl-2, 3-diphenylmorpholin-6-one.
Safety Information:
(2R,3S)-N-tert-butoxycarbonyl-2, 3-diphenylmorpholin-6-one is generally stable and relatively safe. However, as an organic compound, the following safety precautions still need to be paid attention:
-Avoid contact with skin and eyes;
-avoid inhalation or ingestion;
-Pay attention to good ventilation conditions when using;
-Store in a dry, cool place, away from fire and oxidizing agents.
Last Update:2024-04-09 19:05:45